The somatic mode: doing good in targeted cancer therapy

Research output: Contribution to journal › Journal article › Research › peer-review

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The somatic mode : doing good in targeted cancer therapy. / Bogicevic, Ivana; Rohrberg, Kristoffer Staal; Hogdall, Estrid; Svendsen, Mette N.

In: New Genetics and Society, Vol. 40, No. 2, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bogicevic, I, Rohrberg, KS, Hogdall, E & Svendsen, MN 2021, 'The somatic mode: doing good in targeted cancer therapy', New Genetics and Society, vol. 40, no. 2. https://doi.org/10.1080/14636778.2020.1799345

APA

Bogicevic, I., Rohrberg, K. S., Hogdall, E., & Svendsen, M. N. (2021). The somatic mode: doing good in targeted cancer therapy. New Genetics and Society, 40(2). https://doi.org/10.1080/14636778.2020.1799345

Vancouver

Bogicevic I, Rohrberg KS, Hogdall E, Svendsen MN. The somatic mode: doing good in targeted cancer therapy. New Genetics and Society. 2021;40(2). https://doi.org/10.1080/14636778.2020.1799345

Author

Bogicevic, Ivana ; Rohrberg, Kristoffer Staal ; Hogdall, Estrid ; Svendsen, Mette N. / The somatic mode : doing good in targeted cancer therapy. In: New Genetics and Society. 2021 ; Vol. 40, No. 2.

Bibtex

@article{0386c9e5f0a74d21b1c758315ba19508,
title = "The somatic mode: doing good in targeted cancer therapy",
abstract = "This article explores the ethical challenges following the use of genetic information in experimental cancer treatment. In Danish healthcare, current ethical debates on the wider use of genetic information are highly focused on the heredity of genetic information. This focus accords with the international bioethical literature and the established practices of assessing inherited risks for cancer. Drawing on Pols' (2003. {"}Enforcing Rights or Improving Care? The Interference of two Modes of Doing Good in Mental Health Care.{"}Sociology of Health & Illness25 (4): 320-347. doi:10.1111/1467-9566.00349) concept ofmodes of doing good, we show that this has led to a certain understanding of the ethical challenges regarding genetic information - an understanding we term thegermline mode. We argue that the germline mode overlooks crucial dilemmas facing healthcare professionals who use genetic information to target treatment directly at patients' somatic mutations, i.e. alterations in the DNA occurring only in the tumor. In this article, we develop the concept of thesomatic modeand explore the ethical challenges that emerge when genetic information takes a somatic turn.",
keywords = "genomic medicine, oncology, ethics, personalized medicine, genetic testing",
author = "Ivana Bogicevic and Rohrberg, {Kristoffer Staal} and Estrid Hogdall and Svendsen, {Mette N.}",
year = "2021",
doi = "10.1080/14636778.2020.1799345",
language = "English",
volume = "40",
journal = "New Genetics and Society",
issn = "1463-6778",
publisher = "Routledge",
number = "2",

}

RIS

TY - JOUR

T1 - The somatic mode

T2 - doing good in targeted cancer therapy

AU - Bogicevic, Ivana

AU - Rohrberg, Kristoffer Staal

AU - Hogdall, Estrid

AU - Svendsen, Mette N.

PY - 2021

Y1 - 2021

N2 - This article explores the ethical challenges following the use of genetic information in experimental cancer treatment. In Danish healthcare, current ethical debates on the wider use of genetic information are highly focused on the heredity of genetic information. This focus accords with the international bioethical literature and the established practices of assessing inherited risks for cancer. Drawing on Pols' (2003. "Enforcing Rights or Improving Care? The Interference of two Modes of Doing Good in Mental Health Care."Sociology of Health & Illness25 (4): 320-347. doi:10.1111/1467-9566.00349) concept ofmodes of doing good, we show that this has led to a certain understanding of the ethical challenges regarding genetic information - an understanding we term thegermline mode. We argue that the germline mode overlooks crucial dilemmas facing healthcare professionals who use genetic information to target treatment directly at patients' somatic mutations, i.e. alterations in the DNA occurring only in the tumor. In this article, we develop the concept of thesomatic modeand explore the ethical challenges that emerge when genetic information takes a somatic turn.

AB - This article explores the ethical challenges following the use of genetic information in experimental cancer treatment. In Danish healthcare, current ethical debates on the wider use of genetic information are highly focused on the heredity of genetic information. This focus accords with the international bioethical literature and the established practices of assessing inherited risks for cancer. Drawing on Pols' (2003. "Enforcing Rights or Improving Care? The Interference of two Modes of Doing Good in Mental Health Care."Sociology of Health & Illness25 (4): 320-347. doi:10.1111/1467-9566.00349) concept ofmodes of doing good, we show that this has led to a certain understanding of the ethical challenges regarding genetic information - an understanding we term thegermline mode. We argue that the germline mode overlooks crucial dilemmas facing healthcare professionals who use genetic information to target treatment directly at patients' somatic mutations, i.e. alterations in the DNA occurring only in the tumor. In this article, we develop the concept of thesomatic modeand explore the ethical challenges that emerge when genetic information takes a somatic turn.

KW - genomic medicine

KW - oncology

KW - ethics

KW - personalized medicine

KW - genetic testing

U2 - 10.1080/14636778.2020.1799345

DO - 10.1080/14636778.2020.1799345

M3 - Journal article

VL - 40

JO - New Genetics and Society

JF - New Genetics and Society

SN - 1463-6778

IS - 2

ER -

ID: 246778730